Acne vulgaris is a common skin disorder that affects millions of people worldwide, often causing physical illness and psychosocial problems. In recent years, the interest in natural skin care products has increased, which brought to light the investigation of potential anti-acne plant compounds, such as Marigold flower extract, as promising due to its rich phytochemical composition and traditional use in skin care. It was to formulate and find a suitable anti-acne herbal serum. Each of the five-formulation included marigold flower extract along with other plant extract known for their anti-inflammatory and antioxidants properties, like Mint and Aloe vera. To ensure quality and acceptability, the serum solution was thoroughly inspected in physiology, including appearance, texture, scent and pH, Chemical analysis revealed that F5 was the best option; it demonstrated strong efficacy and anti-acne qualities while keeping a light, non-sticky consistency that was ideal for all skin types, This study offers a successful all-natural method of treating acne by examining the advantages of plant and marigold flower extracts for skin.