MEDICINAL PLANTS FOR THE ALLEVIATION OF CHROMIUM-INDUCED TISSUE TOXICITY: A COMPREHENSIVE REVIEW

The accumulation of the heavy metal chromium (Cr) in different organs such as liver, kidneys, heart, and lungs can cause a negative impact on human health. Inhalation is one of the most frequent ways that people are exposed to Cr, and it is linked to harm. Much of the damage produced by Cr poisoning has been related to increased generation of reactive oxygen species (ROS). The body's antioxidant system balance has been observed to be impacted by a redox imbalance brought on by Cr-induced ROS-mediated oxidative stress. Thus, the positive impact of antioxidant nutrients through exogenous antioxidant molecule supplementation may be linked to either lowering the likelihood of Cr interacting with essential biomolecules and causing oxidative damage or enhancing the antioxidant defenses of the cell. This review addresses to discuss the advantageous effect of herbal plants in tissue damage caused by chromium.

• Kawanishi, S.; Hiraku, Y.; Murata, M.; Oikawa, S. 2002. The role of metals in site-specific DNA damage with reference to carcinogenesis. Free Radic Biol Med., 32(9): 822-832. 
• ATSDR. 2000. "Toxicological Profile for Chromium." U.S. Department of health and human services. 
• Dhatrak, S.; Nandi, S. S. 2009. Risk assessment of chronic poisoning among Indian metallic workers. Indian J Occup Environ Med., 13(2): 60.
• Patlolla, A. K.; Barnes, C.; Yedjou, C.; Velma, V.R.; Tchounwou, P.B. 2009. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol., 24(1): 66-73.
• Donaldson, R. M.; Barreras, R. F. 1966. Intestinal absorption of trace quantities of chromium.  J Lab Clin Med., 68(3): 484-493.
• Anderson, R. A. 1997. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr., 16(5): 404-410. 
• Valko, M.; Morris, H.; Cronin, M. T. D. 2005. Metals, toxicity and oxidative stress. Curr Med Chem., 12(10): 1161-1208.
• Nayak, R. S.; Khanna, B.; Pasha, A.; Vinay, K.; Narayan, A.; Chaitra, K. 2015. Evaluation of nickel and chromium ion release during fixed orthodontic treatment using inductively coupled plasma-mass spectrometer: An in vivo study. J Int Oral Health., 7(8): 14-20.
• Clarkson, T.W.; Friberg, L.; Nordberg, G.G.; Sager, P.R. 1988. Biological monitoring of toxic metals. Springer. Doi: 10.1007/978-1-4613-0961-1
• Langård, S.; Vigander, T. 1983. Occurrence of lung cancer in workers producing chromium pigments. Br J Ind Med., 40(1): 71-74.
• Zhitkovich, A.; Song, Y.; Quievryn, G.; Voitkun, V. 2001. Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr (VI) with cysteine: role of ternary DNA adducts in Cr (III)-dependent mutagenesis. Biochem., 40(2):      549-560.
• Mathur, A. K.; Chandra, S. V.; Tandon, S. K. 1977. Comparative toxicity of trivalent and hexavalent chromium to rabbits II. Morphological changes in some organs. Toxicol., 8(1): 53-61.
• Dayan, A. D.; Paine, A. J. 2001. Mechanisms of chromium toxicity, carcinogenicity and allergenicity: review of the literature from 1985 to 2000. Hum Expl Toxicol., 20(9): 439-451.
• IARC. 1990. International Agency for Research on Cancer. Monographs on the evaluation of the carcinogenic risk to humans, IARC, Chromium, Nickel and welding, Vol-49, 677, ISBN; 92 832 1249 5.
• Zhang, X. H., et al. 2011. Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers. BMC Public Health, 11(1): 224.
• Avila-Rojas, S. H., et al. 2020. Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol., 145: 111774.
• Berndt, W. O. 1976. Renal chromium accumulation and its relationship to chromium-induced nephrotoxicity. J Toxicol Environ Health, 1(3):   449-459.
• De Smet PAGM, Keller K, Hansel R, Frank Chandler R. 1997. Adverse Effects of Herbal Drugs. Germany: Springer-Verleg, 1-13. DOI: https://doi.org/10.1007/978-3-642-60367-9
• Trivedi, S.P.; Prasad, R.; Khan, A.A. 2020. Amelioration potential of Withania somnifera root extract on hexavalent chromium induced micronucleus in Channa punctatus (Bloch, 1793). J Environ Biol., 41: 677–684.
• Mansour, H.H; Hafez, H.F. 2012. Protective effect of Withania somnifera against chromium-induced hepatotoxicity in experimental rats. Ecotoxicol Environ Saf., 80: 14-19.
• Gupta, S.C.; Prasad, S.; Tyagi, A.K.; Kunnumakkara, A.B.; Aggarwal, B.B. 2016. Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis. Phytomed., 34: 14-20.
• Sarah, R.; Tabassum, B.; Idrees, N.; Hussain, M.K. 2019. Bioactive compounds isolated from neem tree and their applications. In book: Natural Bio-active Compounds Sub Volume 1 Production and application, Publisher: Springer. DOI:10.1007/978-981-13-7154-7_17
• Kitbumrungsap, P.; Suntornwat, O.; Rayanil, K. (2011). Mangiferin and antioxidant capacity from Mangifera indica leaves extracts. Health & Environ Res., 44(5): 62–66.
• Biswas, S.; Talukder, G.; Sharma, A. 1999. Prevention of cytotoxic effects of chromium by Allium sativum L. extract. Cytobios., 99(394):          13-21.
• Dey, S.; Dey, S.K. 2021. Ameliorative role of garlic (Allium sativum) on chromium (VI)-induced membrane damage in male albino rats. Asian Journal of Pharmaceutical and Clinical Research, 14(9): 69-72.
• Koul, A.; Mallick, T.; Chugh, N. A. 2024. Aloe vera (L.) Burm.f. renders protection against chromium-induced damage in mice: A preliminary study on renal and testicular tissues. Ind J Nat Prod Resources, 15(3): 449-461.
• Pandey, A. K.; Gautam, A.; Pandey, P.; Dubey, R. S. 2018. “Alleviation of chromium toxicity in rice seedling using Phyllanthus emblica aqueous extract in relation to metal uptake and modulation of antioxidative defense. South African J Bot., 121: 306-316.
• Mosaad, A.; Wahhab, A.; Ahmed, H.H. 2004. Protective Effect of Korean Panax ginseng against Chromium Ⅵ Toxicity and Free Radicals Generation in Rats. J Ginseng Res., 28(1): 11-17.
• Jiang, Y. Lv, H.; Li, S.; Han, B.; Liu, Y.; Yang, D.; Li, J.; Yang, Q.; Wu, P.; Zhang Z. 2020. Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3β/Fyn pathway. Chemico-Biol Interact, 317: 108960. 
• Dolai, D.P.; Roy, S.; Dey, S.K. 2020. Study the protective efficacy of mixed solvent extract of Andrographis paniculata Neesin different proportions against chromium (VI)-induced toxicity. European J Pharma Med Res., 7(4): 457-464.
• Babu, K.; Maheswari, K.C.U. 2006. In vivo studies on the effect of Ocimum sanctum L. leaf extract in modifying the genotoxicity induced by chromium and mercury in Allium root meristems. J Environ Biol,. 27(1): 93-95.