DEVELOPMENT OF A NATURAL TOOTH GEL: A STUDY ON NEEM AND GINGER BASED FORMULATION

The goal of the study was to create and assess Tooth gel with Neem and Ginger as the main ingredient to treat dental caries. It is chosen for the treatment of dental caries because of its broad range of antibacterial activity against several dental caries pathogens. The creation the assessment of a tooth gel for the treatment of dental conditions is the primary goal of this project. Globally, dental disease is a serious health issue. Neem and Ginger is used as a medicinal agent, Carbopol 940/Tragacanth used as a gelling agent, Sodium benzoate is used as a preservative, glycerine is used as a humectant, Sorbitol is used as a sweetener, Peppermint oil is used as a Flavouring agent give, after flavouring agent, Triethanolamine as a PH adjuster and the necessary amount of distilled water is used as a vehicle. The gel's phytochemical screening was performed. The gel's appearance and viscosity were assessed, and the findings were excellent. The prepared Natural tooth gel was evaluated for various properties such, as PH spreadability, homogeneity, odour, appearance. The Carbopol based formulation (F1) exhibited superior clarity, smoothness, spreadability, and stability compared to the based formulation(F2). Both formulations maintained PH within the acceptable oral range (6.5-7.0). The results indicate that the optimized Carbopol gel (F1) provides better physical properties Hence, the developed herbal tooth gel represents a safe, effective, and friendly alternative for maintaining oral hygiene and preventing dental infections.

• Haque M, Singh AK, Maurya SK, Seth A. Formulation development, physico-chemical characterization and evaluation of anti-microbial activity of herbal tooth gel. J Chem Pharm Res., 2014; 6(3): 1279-85. 
• Featherstone JD, Fontana M, Wolff M. Novel anticaries and remineralization agents: future research needs. Journal of dental research, 2018 Feb; 97(2): 125-7. 
• Devi BP, Rama subramania raja R. Dental caries and medicinal plants-An overview. J Pharm Res., 2009 Nov; 2(11): 1669-75. 
• Jain I, Jain P, Bisht D, Sharma A, Srivastava B, Gupta N. Use of traditional Indian plants in the inhibition of caries-causing bacteria-Streptococcus mutans. Brazilian dental journal, 2015 Mar; 26:  110-5. 
• Silva TM, Fonseca BM, Sales AL, Holleben P, Valera MC, AraÚjo MA. Effects of fluoride and Aloe vera tooth gel in artificial white spot lesions in vitro. RGO-RevistaGaúcha de Odontologia, 2016 Jan; 64: 56-61. 
• Baby AR, Freire TB, Marques GD, Rijo P, Lima FV, Carvalho JC, Rojas J, Magalhães WV, Velasco MV, Morocho-Jácome AL. Azadirachta indica (Neem) as a potential natural active for dermocosmetic and topical products: A narrative review. Cosmetics, 2022 Jun 2; 9(3): 58. 
• Wylie MR, Merrell DS. The antimicrobial potential of the neem tree Azadirachta indica. Frontiers in pharmacology, 2022 May 30; 13: 891535. 
• Salam R, Sarker BK, Haq MR, Khokon JU. Antimicrobial activity of medicinal plant for oral health and hygiene. Int j nat soc sci., 2015; 1(2): 1-2. 
• Alzohairy MA. Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evidence‐Based Complementary and Alternative Medicine, 2016; 2016(1): 7382506. 
• Naik MR, Bhattacharya A, Behera R, Agrawal D, Dehury S, Kumar S. Study of anti-inflammatory effect of neem seed oil (Azadirachta indica) on infected albino rats. Journal of Health Research and Reviews (In Developing Countries), 2014 Sep 1; 1(3): 66-9.
• Agboola OE, Agboola O, Ayinla ZA, Agboola SS, Olaiya OE, Oyinloye OM, Fajana OM, Idowu OT, Omotuyi OI, Ilesanmi OS, Oyinloye BE. Integrated Virtual Screening for Anti-Caries Compounds from Neem: Dual-Target Inhibition of Biofilm Formation and Bacterial DNA Replication. Biomedicines, 2025 Sep 8; 13(9): 2202. 
• Gupta A, Verma U, Lal N, Ojha S. Evolution and exploration of Azadirachta indica in dentistry: an update. British Journal of Medicine and Medical Research, 2017 Jan 10; 21(8): 1-5. 
• Dewangan C, Sahu SK, Patel D, Sinha D, Sahu S, Sahu Y, Nema RK. Formulation and Development of Dental Gel for Anti-Inflammatory as Well As Analgesic Effect. International Journal of Scientific Research and Technology, 2025 Jun 13; 2(6). 
• Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food and chemical Toxicology, 2008 Feb 1; 46(2): 409-20. 
• Remadevi R, Surendran E, Ravindran PN. Properties and medicinal uses of ginger. InGinger, 2016 Apr 19; (pp. 509-528). 
• Un Nabi SA, Sheraz MA, Ahmed S, Mustaan N, Ahmad I. Pharmaceutical gels: a review. RADS J. Pharm. Pharm. Sci., 2016 Jun 19; 4: 40-8. 
• Pandey, A., Tripathi, S., & Tripathi, Y. B. (2014). Extraction and Evaluation of Bioactive Compounds from Neem (Azadirachta indica A. Juss.) Using Soxhlet Extraction Method. International Journal of Pharma and Bio Sciences, 5(4): 305–312. 
• Umeoka N. Phytochemical and Proximate Screening of Ginger Rhizome (Zingiber Officinale) as a Medicinal Plant. Journal of Health, Wellness and Safety Research, 2024 May 31; 4(3). 
• Shaikh JR, Patil M. Qualitative tests for preliminary phytochemical screening: An overview. International journal of chemical studies, 2020 Mar 1; 8(2):      603-8. 
• Shahidulla SM, Begum S, Atif S, Haneef S. Formulation and In Vitro Evaluation of Dental Gel by Using Melaleuca alternifolia Oil, 2024 July 7; (14). 
• Chavan S, Nadre S, Nawale R, Nayak A, Paikrao A. Review on Formulation And Evaluation of Ayurvedic Tooth Gel, 2024; 2(2): 479-487.