STUDY OF IN-VITRO DRUG RELEASE OF DICLOFENAC MICROSPHERE S WITH DIFFERENT POLYMERS

This research aims to develop diclofenac sodium microspheres using sodium alginate and other polymers such as ethyl cellulose, eudragit and HPMC. The microspheres were prepared using the ionotropic gelation method. The polymer “concentrations were varied to study their effect on the in-vitro drug release of the microspheres. The microspheres followed zero order kinetics and had a drug release pattern that was divided into different ranges.

• Lachman/Lieberman's Theory and Practice of Industrial Pharmacy Fourth Edition Editors Roop Khar SP Vyas Farhan J Ahmad Gaurav K Jain 2016.
• Chein. Y. W., In: Chein, Y. W., (Ed.). Novel Drug Delivery Systems. 2nd edition, Marcel Dekker. New York, 1992; 139.
• Davies NM, Anderson KE. Clinical Pharmacokinetics of Diclofenac: Therapeutic insights and pitfalls. Clinical Pharmacokinetics, 1997; 33(3): 184-213.
• PA, Sorkin EM. Diclofenac sodium - A reappraisTodd al of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs, 1988; 35(3): 244-85.
• Kathleen Parfitt and Martindale. The complete Drug reference part-I, Anti-inflammatory drugs and antipyretics, 32nd edition. Philadelphia Pharmaceutical Press, 1996; 1-11.
• Peter, Merry. New hope for NSAIDs. The Eastern Pharma., 1997; 3340.
• Patric B. Deasy. Microencapsulation and related drug processes. Drugs and Pharmaceutical Sciences series. 2nd edition, Marcel Dekker. New York. Journal of Pharmaceutical Sciences, 1984; 1-22.
• Chowdary and Sri Ramamurthy A. Microencapsulation in Pharmacy. Indian Drugs, 1992; 25(10): 389-392.
• Chaudhari A, Jadhav KR, Kadam VJ. An Overview: Microspheres as a Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences Review and Research, 2010; 5(1): 8-17.
• Pandey R & Sharma A. Poly (D-Lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. Journal of Antimicrobial Chemotherapy, 2003; 52: 981–986.
• Pandey A., Nikam A. N., Mutalik S. P., Fernandes G., Shreya A. B., Pandya B. S. & Raychaudhuri.
• R. Architectured therapeutic and diagnostic nanoplatforms for combating SARS-cov-2: Role of inorganic, organic, and radioactive materials. ACS Biomaterials Science & Engineering, 2021; 7(1):   31–54.
• Barahuie F., Dorniani D., & Saifullah B. Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug delivery system. International Journal of Nanomedicine, 2017; 12: 2361–2372.
• Latif S., Batool N., Shaukat S., Afzal F., and Arshad S. Microparticulate drug delivery system of diclofenac sodium: Formulation development and in-vitro evaluation. International Journal of Biology, Pharmacy and Allied Sciences, 2016; 5(11).
• Manjanna K.M, Shivakumar B., Pramod kumar T.M. Diclofenac Sodium Microbeads for oral sustained drug delivery. International Journal of PharmTech Research, 2009; 1(2): 317-327.